ISIS — Photo courtesy of National Defense University Press On October 16, 2025, an ISIS explosive device struck a Syrian Energy Ministry bus traveling between Deir ez-Zor and al-Mayadin, killing four security personnel and injuring nine, according to state media. ISIS remains very much active in Syria, and its attacks are once again on the rise. Following the overthrow of Syrian President Bashar al-Assad’s regime in December 2024, the U.S. Department of Defense reaffirmed that its mission to defeat ISIS in Syria remains ongoing. Deputy Pentagon Press Secretary Sabrina Singh stated that U.S. Central Command (CENTCOM), along with regional partners, will continue operations to prevent ISIS from reestablishing a foothold in the country. On December 7, 2024, U.S. forces conducted precision airstrikes in central Syria,…

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